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Trial Glossary

LEUKAEMIA AND MYELODYSPLASTIC SYNDROME

AALL0232

A trial investigating high dose methotrexate compared with escalating Capizzi methotrexate plus asparaginase in newly diagnosed patients with high-risk B-cell precursor acute lymphoblastic leukaemia who had previously received prednisone or dexamethasone as induction/consolidation therapy

AML 16

A trial looking at treatment for acute myeloid leukaemia and high risk myelodysplastic syndrome

CLASSIC

A trial investigtating clofarabine plus cytarabine versus cytarabine alone in older patients with relapsed or refractory acute myelogenous leukaemia

COSMIC

A phase II, multi-centre, randomised, open, parallel group trial investigating combination fludarabine and cyclophosphamide plus ofatumumab at standard or mega dose in chronic lymphoid leukemia (CLL)

DASA-TRAS

A pilot study investgating the efficacy and safety of dasatinib after allogeneic stem cell transplantation in patients with de novo Philadelphia positive (bcr-abl+) acute lymphoblastic leukemia

DASISION

A trial investigating dasatinib versus imatinib in chronic phase chronic myeloid leukaemia

ENESTnd

A trial comparing nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia

Leukaemia Lymphoma Research and NCRI Working Group Pick a Winner Programme (LI-1) Trial

A multicentre phase II/III interventional study comparing standard care treatment for acute myeloid leukaemia patients over the age of 60 not fit for intensive chemotherapy in combination with novel agents versus novel agents alone

ML 17 

A trial looking at treatment for acute promyelocytic and acute myeloid leukaemias

DEC-MDS

A trial looking at decitabine for myelodysplastic syndrome and acute myeloid leukaemia

FB - ATG 

A trial looking at mini stem cell transplants for myelodysplastic syndrome and acute myeloid leukaemia

MARALL

A study looking at adding a type of biological therapy to chemotherapy for acute lymphoblastic leukaemia that has come back after treatment

PICCLe

A Phase I/II clinical trial investigating the efficacy and safety of olaparib, a poly (ADP-ribose) polymerase (PARP) -inhibitor, in relapsed and refractory chronic lymphocytic leukaemia patients with an 11q deletion or ATM mutation and relapsed/refractory patients with T-prolymphocytic leukaemia and mantle cell lymphoma

The CONTINUUM Trial

A trial looking at lenalidomide (Revlimid) for B cell chronic lymphocytic leukaemia that has responded to second line chemotherapy

UKALL 2003

A trial looking at chemotherapy for children and young people with acute lymphoblastic leukaemia

LYMPHOMA

CHOP-CAMPATH

A study of CHOP and Campath for peripheral T cell lymphoma

EMERGE

A trial looking at lenalidomide for mantle cell lymphoma

FORT

A trial looking at radiotherapy for people with follicular lymphoma or marginal zone lymphoma

GemBex

A trial looking at gemcitabine and bexarotene for people with T cell lymphoma of the skin

MCL MiniAllo 

A trial of low intensity transplants for mantle cell lymphoma

PACIFICO

A trial looking at rituximab and chemotherapy as a treatment for follicular lymphoma in elderly patients

PAIReD 

A trial looking at high dose chemotherapy and stem cell transplants for people with Hodgkin's lymphoma

PRIMA 

A trial investigating the benefit of maintenance therapy with rituximab as measured by progression-free survival (PFS) compared with no maintenance therapy after induction of response with chemotherapy plus rituximab in patients with high tumor burden follicular lymphoma

PROPEL 

A trial investigating whether pralatrexate injection may reverse the pattern of progressive resistance observed in patients with relapsed or refractory peripheral T-cell lymphoma

RATHL

A trial looking at PET scans and treatment for Hodgkin's lymphoma

R-CHOP 14 vs R-CHOP 21

A trial looking at treatment every 2 weeks or every 3 weeks for non Hodgkin's lymphoma

R-CODOX-M/IVAC for DLBCL or BL 

A trial looking at chemotherapy and rituximab for people with diffuse large B cell non Hodgkin's lymphoma or Burkitt's lymphoma

ReACH

A trial looking at high dose chemotherapy and stem cell transplants for people with Hodgkin's lymphoma that has come back for the first time

RIC UCBT

A trial of stem cell transplants using umbilical cord blood

SPIRIT 2 

A trial looking at imatinib and dasatinib for newly diagnosed chronic myeloid leukaemia

SWOG S9704 

A trial investigating autologous stem-cell transplantation in patients with high-intermediate or high International Prognostic Index risk diffuse aggressive non-Hodgkin’s lymphoma who have objective responses to cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP)-based induction therapy

The 18 to 30 study 

A trial looking at chemotherapy for young people with Hodgkin's lymphoma

TOPPS

A trial looking at platelet transfusions during treatment for cancer of the blood or lymphatic system

MYELOMA

ADMYRE 

A trial of plitidepsin in combination with dexamethasone versus dexamethasone alone in patients with relapsed/refractory multiple myeloma

CAFE 

A trial investigating the use of balloon kyphoplasty, a minimally invasive surgical procedure to treat vertebral compression fracture in myeloma patients

CALGB 100104 study 

IFM 2005-02: a trial comparing lenalidomide maintenance therapy or no maintenance post high dose melphalan with peripheral blood stem cell support in younger patients

ELOQUENT – 1 

A Phase III study of lenalidomide and dexamethasone with or without elotuzumab to treat newly diagnosed, previously untreated multiple myeloma

LenaRIC 

A Phase II study of the adjuvant use of lenalidomide in patients undergoing reduced intensity conditioning allogenic transplantation for multiple myeloma

MM5 

A trial investigating two regimens of bortezomib-based induction therapy and of lenalidomide consolidation followed by lenalidomide maintenance treatment in patients with multiple myeloma

MMIFTT 

A trial looking at DNA vaccine therapy after stem cell transplant for myeloma

MRC Myeloma IX trial 

A trial investigating first-line treatment with zoledronic acid versus clodronic acid in newly diagnosed multiple myeloma patients

MUKone 

An open label, multicentre, randomised, parallel group phase II selection trial to identify the optimal starting dose of bendamustine (60 versus 100 mg/m2) when given in combination with thalidomide and dexamethasone in patients with relapsed/refractory multiple myeloma

MUK three 

A trial investigating CHR-3996, a histone deacetylase inhibitor, in combination with tosedostat in subjects with multiple myeloma

Myeloma X Relapse

A trial looking at a second stem cell transplant for people whose myeloma has come back following a previous transplant

PADIMAC

A trial investigating progression-free survival in multiple myeloma for patients who receive no further treatment after achieving a major response to induction therapy with PAD (Bortezomib, Adriamycin and Dexamethasone)

TEAMM

A randomized, double-blind, placebo-controlled multi-centre phase III clinical trial assessing the benefit of antibiotic prophylaxis and its effect on health care associated infections in newly diagnosed myeloma

Unless otherwise indicated, opinions expressed in Haematology Now are those of the contributors.  Although every effort is made to ensure accuracy and avoid mistakes, no liability on the part of the sponsor, publisher, editors or the editorial board is accepted for the consequences of any misleading or inaccurate information.

© 2018 . All rights reserved. 'Viewpoints' photo courtesy of the American Society of Hematology.



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